Recent Highlights

• Structural basis for receptor recognition of vitamin-B₁₂–intrinsic factor complexes
  Folsted Andersen et al.,   Nature 464 445-449 (2010)


• Probing the reaction mechanism of IspH protein by x-ray structure analysis
  Gräwert et al.,   PNAS 107(3), 1077-1081 (2010)


• Origin and temperature dependence of radiation damage in biological samples at cryogenic temperatures
  Meents et al.,   PNAS, doi 10.1073 pnas.0905481107 (2009)


• The atomic structure of baculovirus polyhedra reveals the independent emergence of infectious crystals in DNA and RNA viruses
  Coulibaly et al.,   PNAS, doi 10.1073 pnas.0910686106 (2009)


• Crystal Structure of a Nucleocapsid-Like Nucleoprotein-RNA Complex of Respiratory Syncytial Virus
  Tawar et al.,   Science 326, 1279 - 1283 (2009)


• Bothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234W
  He et al.,   PNAS 106 (44), 18545�18550 (2009)


• An EB1-Binding Motif Acts as a Microtubule Tip Localization Signal
  Honnappa et al.,   Cell 138, 366-376 (2009)


• 3D Imaging of the Fermi Surface by Thermal Diffuse Scattering
  Bosak et al.,   Phys Rev Lett 103, 076403, 4 pp (2009)


• Structural Basis and Enzymatic Mechanism of the Biosynthesis of C₉- from C₁₀-Monoterpenoid Indole Alkaloids
  Yang et al.,   Angew Chem, Int. Ed. 46, DOI: 10.1002/anie.200900150 (2009)


• Novel sample preparation technique for protein crystal X-ray crystallographic analysis combining microfluidics and acoustic manipulation
  Oberti et al.,   J Appl Cryst 42, doi:10.1107/S0021889809019177 (2009)


• McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR
  Fuhrmann et al.,   Science 324, 1323 - 1327 (2009)


• The structure of a cytolytic α-helical toxin pore reveals its assembly mechanism
  Mueller et al.,   Nature 459, 726 - 730 (2009)


• The Structure of Rat Liver Vault at 3.5 Angstrom Resolution
  Tanaka et al.,   Science 323: 384 - 388 (2009)


• Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution
  Pomeranz Krummel et al.,   Nature, 458, 475 - 481 (2009)


• Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome
  Weixlbaumer et al.,   Science, 322, 953 - 956 (2008)


• Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel
  Hilf and Dutzler,   Nature Lett. doi:10.1038 , online 5 Nov 2008 (2008)


• X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
  Boquet et al.,   Nature Lett. doi:10.1038 , online 5 Nov 2008 (2008)


• Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases
  Redondo et al.,   Nature Lett., 456, 107 - 113 (2008)


• The Crystal Structure of a Mammalian Fatty Acid Synthase
  Maier et al.,   Science 321, 1315-1322 (2008)


• Structural Basis of Trans-Inhibition in a Molybdate/Tungstate ABC Transporter
  Gerber et al.,   Science 321, 247-250 (2008)


• Structural basis of transcription inhibition by α-amanitin and implications for RNA polymerase II translocation
  Brueckner et al.,   NSMB 41, advance online publication, (June 2008)


• Reciprocal-space imaging of a real quasicrystal. A feasibility study with PILATUS 6M.
  Weber et al.,   J.Appl. Cryst. 41, (2008)


• A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
  Groll et al.,   Nature 452, 755-759(2008)


• A peptide deformylase-ribosome complex reveals mechanism of nascent chain processing
  Bingel-Erlenmeyer et al.,   Nature 452, 108-113 (2008)


• X-ray structure of a prokaryotic pentameric ligand-gated ion channel
  Hilf et al.,   Nature advance online publ. (doi:10.1038) (2008) supplement. info


• Site selectivity of platinum anticancer therapeutics
  Wu et al.,   Nature Chem. Biol. advance online publ. 3 Jan. 2008


• Designed Protein-Protein Association
  Grueninger et al.,   Science, Vol.319, 206 - 209 (2008)


• Functional Architecture of RNA Polymerase I
  Kuhn et al.,   Cell, 131, 1260 - 1272 (2007)


• Molecular basis of RNA-dependent RNA polymerase II activity
  ( + supplementary information)
  Lehmann et al.,   Nature, 450, 445 - 449 (2007)


• Crystal structure of the sodium-potassium pump
  Morth et al.,   Nature 450, 1043 - 1049 (2007)


• Crystal structure of the plasma membrane pump
  Pedersen et al.,   Nature 450, 1011 - 1014 (2007)


• Bypass of DNA Lesions Generated During Anticancer Traetment with Cisplatinby DNA Polymerase η
  Alt et al.,   Science, Vol.318, 967-970 (2007)


• Structure of an ABC transporter in complex with its binding protein
  Hollenstein et al.,   Nature, publ. online, doi: 10.1038/nature05626 (2007)


• Structure of Fungal Fatty Acid Synthase and Implications for Iterative Substrate Shuttling
  Jenni et al.,   Science, Vol.316, 254-261 (2007)


• Structural Basis for Substrate Delivery by Acyl Carrier Protein in the Yeast Fatty Acid Synthase
  Leibundgut et al.,   Science, Vol.316, 288-290 (2007)


• The molecular organization of cypovirus polyhedra
  Coulibaly et al.,   Nature, 446, 97-101 (2007)


• Adenovirus type 11 binding alters the conformation of its receptor CD46
  Persson et al.,   NSMB, 14 (2), 164-166 (2007)


• Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5
  Meyer et al.,   NSMB, 14 (2), 60-67 (2007)


• Structure of an ABC transporter in complex with its binding protein
  Hollenstein et al.,   Nature, publ. online, doi: 10.1038/nature05626 (2007)


• CPD Damage Recognition by Transcribing RNA Polymerase II
  Brueckner et al.,   Science, Vol.315, 859-862 (2007)


• Structure of the Prefusion Form of the Vesicular Stomatitis Virus Glycoprotein G
  Roche et al.,   Science, Vol.315, 843-848 (2007)


• X-ray structure of the membrane-bound cytochrome c quinol dehydrogenase NrfH reveals novel haem coordination
  Rodrigues et al.,   EMBO J., 25, 5951-5960 (2006)


• Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
  Jauch et al.,   EMBO J., 25, 4020-4032 (2006)


• Structural basis for messenger RNA movement of the ribosome
  Yusupova et al.,   Nature, 444, 391-394 (2006)


• The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation
  Schluenzen et al.,   NSMB, 13, 10, 871-878 (2006)


• Structure of the 70S Ribosome Complexed with mRNA and tRNA
  Selmer et al.,   Science, 313, 1935-1942 (2006)


• Structure of a bacterial multidrug ABC transporter
  Dawson and Locher, Nature online doi: 10.1038/nature05155 (2006)


• The Crystal Structure of the Exon Junction Complex Reveals How It Maintains a Stable Grip on mRNA
  Bono et al., Cell, 126, 713-725 (2006)


• Structural Asymmetry of AcrB Trimer suggests a Peristaltic Pump Mechanism
  Seeger et al., Science, 313, 1295-1298 (2006)


• Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20
  Larivière et al., NSMB, 13, 895-901 (2006)


• Crystal Structure of the Low-pH Form of the Vesicular Stomatitis Virus Glycoprotein G
  Roche et al., Science, 313, 187-191 (2006)


• Structural Biology of RNA Polymerase III: Subcomplex C17/25 X-ray Structure and 11 Subunit Enzyme Model
  Jasiak et al., Molecular Cell, 23, 71-81 (2006)


• Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment
  Jauch et al.,   EMBO J., 25, 4020-4032 (2006)


• Structure of the monomeric outer-membrane porin OmpG in the open and closed conformation
  Yildiz et al.,   EMBO J., 25, 3702-3713 (2006)


• Escherichia coli acid resistance: pH-sensing, activation by chloride and autoinhibition in GadB
  Gut et al., EMBO J., 25, 2643-2651 (2006)


• Structure of the unusual seryl-tRNA synthetase reveals a distinct zinc-dependent mode of substrate recognition
  Bilokapic et al., EMBO J., 25, 2498-2509 (2006)


• Structure of the Eukaryotic Thiamine Pyrophosphate Riboswitch with Its Regulatory Ligand
  Thore et al., Science, 312, 1208-1211 (2006)


• Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY
  Mirza et al.,   EMBO J. 25, 1177-1183 (2006)


• Undressing of Phosphine Gold(I) Complexes as Irreversible Inhibitors of Human Disulfide Reductases
  Urig et al.,   Angewandte Chemie Int. Ed., 45,1881-1886 (2006)


• Architecture of Mammalian Fatty Acid Synthase at 4.5 Å Resolution
  Maier et al.,   Science, Vol.311, 5765, 1258-1262 (2006)


• Architecture of a Fungal Fatty Acid Synthase at 5 Å Resolution
  Jenni et al.,   Science, Vol.311, 5765, 1263-1267 (2006)


• Ion-binding properties of the ClC chloride selectivity filter
  Lobet and Dutzler,   EMBO J. 25, 24-33 (2006)


• Structure of an RNA polymerase II-RNA inhibitor complex elucidates transcription regulation by noncoding RNAs
  Kettenberger et al.,   NSMB, 13 (1), 44-48 (2006)


• Structural mechanism of plant aquaporin gating
  Törnroth-Horsefield et al.,   Nature online doi:10.1038/natureO4316, December (2005)


• Structure of a central stalk subunit F of prokaryotic V-type ATPase/synthase from Thermus thermophilus.
  Makyio et al.,   EMBO J., 24, 3974-3983 (2005)


• Structural Framework for the Mechanism of Archaeal Exosomes in RNA Processing
  Büttner et al.,   Molecular Cell, 20 (39), 461-471 (2005)


• Structural Basis of 3' End RNA Recognition and
  Exoribonucleolytic Cleavage by an Exosome RNase PH Core
  Lorentzen and Conti,   Molecular Cell, 20 (39), 473-481 (2005)


• A conserved trimerization motif controls the topology of short coiled coils
  Kammerer et al.,   PNAS, 102 (39), 13891-13896 (2005)
  (This paper is based on the first data-set ever collected at X06SA in July 2001!)


• The HIV-1 capsid protein C-terminal domain in complex with a virus assembly inhibitor
  Ternois et al.,   NSMB, 12 (8), 687-682 (2005)


• Structure of a type II thymidine kinase with bound dTTP,
  Birringer et al.,   FEBS Lett. 579, 1376-1382 (2005)


• X-ray structure of a tetranucleosome and its implications for the chromatin fibre,
  Schalch et al.,   Nature, vol. 436, 138-141 (2005)


• Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH,
  Hunte et al.,   Nature, vol. 435, 1197-1202 (2005)


• The archaeal exosome core is a hexameric ring structure with three catalytic subunits,
  Lorentzen et al.,   NSMB, publ. online at http://www.nature.com/nsmb/, 18 May (2005)


• Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD,
  Nishiyama et al.,   EMBO J., 24, 2075-2086(2005)


• X-Ray Structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase Core and its Complex with DNA,
  Dürr et al.,   Cell, 121, 363-373 (2005)


• Structure of the Rotor Ring of F-Type Na⁺-ATPase from Ilyobacter tartaricus,
  Meier et al.,   Science, 308, 659-662 (2005)


• Translational Operator of mRNA on the Ribosome: How Repressor Proteins Exclude Ribosome Binding,
  Jenner et al.,   Science, 308, 120-123 (2005)


• The Birnavirus Crystal Structure Reveals Structural Relationships among Icosahedral Viruses,
  Coulibaly et al.,   Cell, 120, 761-772 (2005)


• Selenocystein tRNA-specific elongation factor SelB is a structural chimaera of elongation and initiation factors,
  Leibundgut et al.,   EMBO J., Jan 26;24(2):11-22 (2005)


• X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF
  on the 50S ribosomal subunit,
  Wilson et al.,   EMBO J., Jan 26;24(2):251-60 (2005)


• Complete RNA polymerase II elongation complex structure and its iteration with NTP and TFIIS,
  Kettenberger et al.,   Molecular Cell, vol. 16, 955-965 (2004)


• Structure and mechanisms of RNA polymerase II CTD phosphatases,
  Kamenski et al.,   Molecular Cell, vol. 15, 399-407 (2004)


• The core FH2 domain of diphanous-related formins is an elongated actin binding protein
  that inhibits polymerization,
  Shimada et al.,   Molecular Cell, vol. 13, 511-522 (2004)


• Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase,
  Thoma et al.,   Nature, vol. 432, 118-122 (2004)


• Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins,
  Ferbiz et al.,   Nature, vol. 431, 590-596 (2004)


• Recognition of RNA polymerase II carboxy-terminal domain by 3'-RNA processing factors,
  Meinhart and Cramer,   Nature, vol. 430, 223-226 (2004)


• Crystal Structure of 4-hydroxybutyryl-CoA dehydratase: Radical catalysis involving a [4Fe-4S] cluster and flavin,
  Martins et al.,   PNAS, vol.101, 44, 15645-15649 (2004)


• Architecture of the Photosynthetic Oxygen-Evolving Center,
  Ferreira et al.,   Science, vol.303, 1831-1838 (2004)


• Crystal Structure of a Photolyase Bound to a CPD-Like DNA Lesion After in Situ Repair,
  Mees et al.,   Science, vol.306, 1789-1793 (2004)


• Structural basis of activity and allosteric control of diguanylate cyclase,
  Chan et al.,   PNAS, vol.101, no.49, 17084-17089 (2004)


• The mechanism of ammonia transport based on the crystal structure of AmtB of Escherichia coli, Zheng et al.,
    PNAS, vol.101, no.49, 17090-17095 (2004)


• Protein Crystallography with the PILATUS 1M Detector at the Swiss Light Source,  SRN, Vol. 17, No. 2, (2004)
  
  
• Molecular recognition of BMP-2 and BMP receptor IA,
  Keller et al., Nat. Struct. Mol. Biol., 11(5), 481-488, (2004)
  


• Structure of a bifunctional DNA primase-polymerase,
  Lipps et al., Nat. Struct. Mol. Biol., 11(2), 157-162, (2004)
  
  
• Conformational change and protein-protein interactions of the fusion protein of Semliki Forest virus,
  Gibbons et al., Nature Vol. 427, 320-325 (2004)
  
  
• Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase,
  Iwata et al., PNAS Vol. 101, 59-64 (2004)